Gadolinium/boron-based agents in imaging guided boron neutron capture therapy (BNCT)

A theranostic approach for the treatment of primary tumours and metastasis based on the use of Boron neutron capture therapy (BNCT) that combines low energy neutron irradiation with the presence of boron-containing compound at the targeted cells. The novel theranostic agents are able to maximize the selective uptake of boron atoms in tumour cells and, at the same time, to quantify boron distribution in the tumour and in other tissues by MRI.

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Innovative diagnostic protocols for Fast Field Cycling NMR/MRI

Development of an innovative diagnostic strategy, based on the measurements of T1 at low and ultra-low magnetic fields with Fast Field Cycling (FFC-NMR) to obtain quantitative information on tumour aggressiveness and metastastatic potential, due to different water content and mobility. Differences in T1 are much greater at low field and the shape of the relaxation dispersion profiles may be used as a reporter of the molecular dynamical processes.

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