Journal Papers

    Full list of publications available at PubMed

    |2019

  1. Anemone A, Consolino L, Arena F, Capozza M, Longo DL, Zaiss M, Golay X. "Imaging tumor acidosis: a survey of the available techniques for mapping in vivo tumor pH" Cancer Metastasis Rev. 2019

  2. Kujawa A, Kim M, Demetriou E, Anemone A, Longo DL, Zaiss M, Golay X. "Assessment of a clinically feasible Bayesian fitting algorithm using a simplified description of Chemical Exchange Saturation Transfer (CEST) Imaging" Journal of Magnetic Resonance, 2019, 300, 120

  3. Pagoto A, Tripepi M, Stefania R, Lanzardo S, Longo DL, Garello F, Porpiglia F, Manfredi M, Aime S, Terreno E. "An efficient MRI agent targeting extracellular markers in prostate adenocarcinoma" Magnetic Resonance in Medicine 2019, 81, 1935

  4. |2018

  5. Wu Y, Zhou IY, Igarashi T, Longo DL, Aime S, Sun PZ. "A generalized ratiometric chemical exchange saturation transfer (CEST) MRI approach for mapping renal pH using iopamidol" Magn Reson Med. 2018,79 1553

  6. Srivastava K, Ferrauto G, Harris S, Longo DL, Botta M, Aime S, Pierre V. "Complete On/Off Responsive ParaCEST MRI Contrast Agents for Copper and Zinc" Dalton Transactions 2018, 47, 11346

  7. Goerke S, Breitling J, Zaiss M, Windschuh J, Kunz P, Schuenke P, Paech D, Longo DL, Klika KD, Ladd ME, Bachert P. "Dual-frequency irradiation CEST-MRI of endogenous bulk mobile proteins" NMR in Biomedicine 2018, 31, e3920

  8. Wyart E, Reano S, Hsu MY, Longo DL, Li M, Hirsch E, Filigheddu N, Ghigo A, Riganti C, Porporato PE. "Metabolic Alterations in a Slow-Paced Model of Pancreatic Cancer-Induced Wasting" Oxidative Medicine and Cellular Longevity 2018, in press

  9. Arena F, Irrera P, Consolino L, Colombo Serra S, Zaiss M, Longo DL. "Flip-angle based ratiometric approach for pulsed CEST-MRI pH imaging" J Magn Reson. 2018, 287, 1

  10. |2017

  11. Anemone A, Consolino L, Conti L, Reineri F, Cavallo F, Aime S, Longo DL. "In vivo evaluation of tumour acidosis for assessing the early metabolic response and onset of resistance to dichloroacetate by using magnetic resonance pH imaging" Int J Oncol. 2017, 51, 498

  12. Wu Y, Zhou IY, Igarashi T, Longo DL, Aime S, Sun PZ. "A generalized ratiometric chemical exchange saturation transfer (CEST) MRI approach for mapping renal pH using iopamidol" Magn Reson Med. 2017,xx xx

  13. Longo DL, Moustaghfir FZ, Zerbo A, Consolino L, Anemone A, Bracesco M, Aime S. "Exploiting pharmaceutical excipients as MRI-CEST contrast agents for tumor imaging" Int J Pharm. 2017, 525, 275

  14. Longo DL, Stefania R, Aime S, Oraevsky A. "Melanin-Based Contrast Agents for Biomedical Optoacoustic Imaging and Theranostic Applications" Int J Mol Sci. 2017, 18, E1719

  15. Longo DL, Cutrin JC, Michelotti F, Irrera P, Aime S. "Noninvasive evaluation of renal pH homeostasis after ischemia reperfusion injury by CEST-MRI" NMR Biomed. 2017, 30, xxx

  16. Fagoonee S, Picco G, Orso F, Arrigoni A, Longo DL, Forni M, Scarfò I, Cassenti A, Piva R, Cassoni P, Silengo L, Tolosano E, Aime S, Taverna D, Pandolfi PP, Brancaccio M, Medico E, Altruda F. "The RNA-binding protein ESRP1 promotes human colorectal cancer progression" Oncotarget. 2017, 8, 10007

  17. Consolino L, Longo DL, Sciortino M, Dastrù W, Cabodi S, Giovenzana GB, Aime S. "Assessing tumor vascularization as a potential biomarker of imatinib resistance in gastrointestinal stromal tumors by dynamic contrast-enhanced magnetic resonance imaging" Gastric Cancer. 2017, 20, 629

  18. Longo DL, Stefania R, Callari C, De Rose F, Rolle R, Conti L, Consolino L, Arena F, Aime S. "Water Soluble Melanin Derivatives for Dynamic Contrast Enhanced Photoacoustic Imaging of Tumor Vasculature and Response to Antiangiogenic Therapy" Adv Healthc Mater. 2017, 6, 1600550

  19. Anemone A, Consolino L, Longo DL. "MRI-CEST assessment of tumour perfusion using X-ray iodinated agents: comparison with a conventional Gd-based agent" Eur Radiol. 2017, 27, 2170
  20. |2016

  21. Longo DL, Bartoli A, Consolino L, Bardini P, Arena F, Schwaiger M, Aime S. "In vivo imaging of tumour metabolism and acidosis by combining PET and MRI-CEST pH imaging" Cancer Research 2016, 76, 6463

  22. Consolino L, Longo DL, Dastrù W, Cutrin JC, Dettori D, Lanzardo S, Oliviero S, Cavallo F, Aime S. "Functional imaging of the angiogenic switch in a transgenic mouse model of human breast cancer by dynamic contrast enhanced magnetic resonance imaging" Int J Cancer. 2016, 139, 404

  23. Longo DL, Arena F, Consolino L, Minazzi P, Geninatti-Crich S, Giovenzana GB, Aime S. "Gd-AAZTA-MADEC, an improved blood pool agent for DCE-MRI studies on mice on 1 T scanners" Biomaterials. 2016 , 75, 47

  24. Longo DL, Michelotti F, Consolino L, Bardini P, Digilio G, Xiao G, Sun PZ, Aime S. "In Vitro and In Vivo Assessment of Nonionic Iodinated Radiographic Molecules as Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Tumor Perfusion Agents" Invest Radiol. 2016, 51, 155

  25. Mulas G, Anedda R, Longo DL, Roggio T, Uzzau S. "An MRI method for monitoring the ripening of Grana Padano cheese" International Dairy Journal 2016, 52, 19
  26. |2015

  27. Longo DL, Dastrù W, Consolino L, Espak M, Arigoni M, Cavallo F, Aime S. "Cluster analysis of quantitative parametric maps from DCE-MRI: application in evaluating heterogeneity of tumor response to antiangiogenic treatment" Magn Reson Imaging. 2015, 33, 725

  28. Wu R, Longo DL, Aime S, Sun PZ. "uantitative description of radiofrequency (RF) power-based ratiometric chemical exchange saturation transfer (CEST) pH imaging" NMR Biomed. 2015, 28, 555

  29. Voena C, Menotti M, Mastini C, Di Giacomo F, Longo DL, Castella B, Merlo MEB, Ambrogio C, Wang Q, Minero VG, Poggio T, Martinengo C, D'Amico L, Panizza E, Mologni L, Cavallo F, Altruda F, Butaney M, Capelletti M, Inghirami G, Jänne PA, Chiarle R. "Efficacy of a Cancer Vaccine against ALK-Rearranged Lung Tumors" Cancer Immunol Res. 2015, 3, 1333

  30. Braccini L, Ciraolo E, Campa CC, Perino A, Longo DL, Tibolla G, Pregnolato M, Cao Y, Tassone B, Damilano F, Laffargue M, Calautti E, Falasca M, Norata GD, Backer JM, Hirsch E. "PI3K-C2γ is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signalling" Nat Commun. 2015, 23, 7400

  31. Abate F, Todaro M, van der Krogt JA, Boi M, Landra I, Machiorlatti R, Tabbò F, Messana K, Abele C, Barreca A, Novero D, Gaudiano M, Aliberti S, Di Giacomo F, Tousseyn T, Lasorsa E, Crescenzo R, Bessone L, Ficarra E, Acquaviva A, Rinaldi A, Ponzoni M, Longo DL, Aime S, Cheng M, Ruggeri B, Piccaluga PP, Pileri S, Tiacci E, Falini B, Pera-Gresely B, Cerchietti L, Iqbal J, Chan WC, Shultz LD, Kwee I, Piva R, Wlodarska I, Rabadan R, Bertoni F, Inghirami G; European T-cell Lymphoma Study Group. " A novel patient-derived tumorgraft model with TRAF1-ALK anaplastic large-cell lymphoma translocation" Leukemia. 2015, 29, 1390
  32. |2014

  33. Longo DL, Sun PZ, Consolino L, Michelotti FC, Uggeri F, Aime S. "A general MRI-CEST ratiometric approach for pH imaging: demonstration of in vivo pH mapping with iobitridol" J Am Chem Soc. 2014, 136, 14333

  34. Perino A, Beretta M, Kilić A, Ghigo A, Carnevale D, Repetto IE, Braccini L, Longo DL, Liebig-Gonglach M, Zaglia T, Iacobucci R, Mongillo M, Wetzker R, Bauer M, Aime S, Vercelli A, Lembo G, Pfeifer A, Hirsch E. "Combined inhibition of PI3Kβ and PI3Kγ reduces fat mass by enhancing α-MSH-dependent sympathetic drive" Sci Signal. 2014, 7, ra110

  35. Riccardo F, Arigoni M, Buson G, Zago E, Iezzi M, Longo DL, Carrara M, Fiore A, Nuzzo S, Bicciato S, Nanni P, Landuzzi L, Cavallo F, Calogero R, Quaglino E. "Characterization of a genetic mouse model of lung cancer: a promise to identify Non-Small Cell Lung Cancer therapeutic targets and biomarkers" BMC Genomics. 2014, 15 Suppl 3:S1

  36. Sun PZ, Longo DL, Hu W, Xiao G, Wu R. "Quantification of iopamidol multi-site chemical exchange properties for ratiometric chemical exchange saturation transfer (CEST) imaging of pH" Phys Med Biol. 2014, 59, 4493

  37. Longo DL, Di Gregorio E, Abategiovanni R, Ceccon A, Assfalg M, Molinari H, Aime S. "Chemical exchange saturation transfer (CEST): an efficient tool for detecting molecular information on proteins' behaviour" Analyst. 2014, 139, 2687
  38. |2013

  39. Bandini S, Curcio C, Macagno M, Quaglino E, Arigoni M, Lanzardo S, Hysi A, Barutello G, Consolino L, Longo DL, Musiani P, Forni G, Iezzi M, Cavallo F. "Early onset and enhanced growth of autochthonous mammary carcinomas in C3-deficient Her2/neu transgenic mice" Oncoimmunology. 2013, 2, e26137

  40. Avedano S, Botta M, Haigh JS, Longo DL, Woods M. "Coupling fast water exchange to slow molecular tumbling in Gd3+ chelates: why faster is not always better" Inorg Chem. 2013, 52, 8436

  41. Castelli DD, Terreno E, Longo DL, Aime S. "Nanoparticle-based chemical exchange saturation transfer (CEST) agents" NMR Biomed. 2013, 26, 839

  42. Ceccon A, D'Onofrio M, Zanzoni S, Longo DL, Aime S, Molinari H, Assfalg M. "NMR investigation of the equilibrium partitioning of a water-soluble bile salt protein carrier to phospholipid vesicles" Proteins. 2013, 81, 1776

  43. Casalini F, Fugazza L, Esposito G, Cabella C, Brioschi C, Cordaro A, D'Angeli L, Bartoli A, Filannino AM, Gringeri CV, Longo DL, Muzio V, Nuti E, Orlandini E, Figlia G, Quattrini A, Tei L, Digilio G, Rossello A, Maiocchi A. "Synthesis and preliminary evaluation in tumor bearing mice of new (18)F-labeled arylsulfone matrix metalloproteinase inhibitors as tracers for positron emission tomography" J Med Chem. 2013, 56, 2676

  44. Longo DL, Busato A, Lanzardo S, Antico F, Aime S. "Imaging the pH evolution of an acute kidney injury model by means of iopamidol, a MRI-CEST pH-responsive contrast agent" Magn Reson Med. 2013, 70, 859

  45. Geninatti Crich S, Alberti D, Orio L, Stefania R, Longo DL, Aime S. "Lipid-Based Nanoparticles in Cardiovascular Molecular Imaging" Current Cardiovascular Imaging Reports 2013, 6, 69
  46. |2012

  47. Arigoni M, Barutello G, Lanzardo S, Longo DL, Aime S, Curcio C, Iezzi M, Zheng Y, Barkefors I, Holmgren L, Cavallo F. "A vaccine targeting angiomotin induces an antibody response which alters tumor vessel permeability and hampers the growth of established tumors" Angiogenesis. 2012, 15, 305
  48. |2011

  49. Geninatti-Crich S, Szabo I, Alberti D, Longo DL, Aime S. " MRI of cells and mice at 1 and 7 Tesla with Gd-targeting agents: when the low field is better!" Contrast Media Mol Imaging. 2011, 6, 421

  50. Dastrù W, Longo DL, Aime S. "Contrast agents and mechanisms" Drug Discov Today Technol. 2011, 8, e109

  51. Longo DL, Dastrù W, Digilio G, Keupp J, Langereis S, Lanzardo S, Prestigio S, Steinbach O, Terreno E, Uggeri F, Aime S. "Iopamidol as a responsive MRI-chemical exchange saturation transfer contrast agent for pH mapping of kidneys: In vivo studies in mice at 7 T" Magn Reson Med. 2011, 65, 202

  52. Botta M, Avedano S, Giovenzana GB, Lombardi A, Longo DL, Cassino C, Tei L, Aime S. "Relaxometric Study of a Series of Monoaqua GdIII Complexes of Rigidified EGTA-Like Chelators and Their Noncovalent Interaction with Human Serum Albumin" Eur J Inorg Chem 2011, 6, 802
  53. |2010

  54. Tei L, Mazooz G, Shellef Y, Avni R, Vandoorne K, Barge A, Kalchenko V, Dewhirst MW, Chaabane L, Miragoli L, Longo DL, Neeman M, Aime S. "Novel MRI and fluorescent probes responsive to the Factor XIII transglutaminase activity" Contrast Media Mol Imaging. 2010, 5, 213

  55. de Leva MF, Filla A, Criscuolo C, Tessa A, Pappatà S, Quarantelli M, Bilo L, Peluso S, Antenora A, Longo DL, Santorelli FM, De Michele G. "Complex phenotype in an Italian family with a novel mutation in SPG3A" J Neurol. 2010, 257, 328

  56. Terreno E, Dastrù W, Castelli DD, Gianolio E, Crich SG, Longo DL, Aime S. "Advances in Metal-Based Probes for MR Molecular Imaging Applications" Curr Med Chem. 2010, 17, 3684
  57. |2009

  58. Terreno E, Stancanello J, Longo DL, Castelli DD, Milone L, Sanders HM, Kok MB, Uggeri F, Aime S. "Methods for an improved detection of the MRI-CEST effect" Contrast Media Mol Imaging. 2009, 4, 237

  59. Francalanci F, Avolio M, De Luca E, Longo DL, Menchise V, Guazzi P, Sgrò F, Marino M, Goitre L, Balzac F, Trabalzini L, Retta SF. "Structural and functional differences between KRIT1A and KRIT1B isoforms: a framework for understanding CCM pathogenesis" Exp Cell Res. 2009, 315, 285

  60. Baroni S, Pariani G, Fanali G, Longo DL, Ascenzi P, Aime S, Fasano M. "Thermodynamic analysis of hydration in human serum heme-albumin" Biochem Biophys Res Commun. 2009, 385, 385
  61. |2007

  62. Avedano S, Tei L, Lombardi A, Giovenzana GB, Aime S, Longo DL, Botta M. "Maximizing the relaxivity of HSA-bound gadolinium complexes by simultaneous optimization of rotation and water exchange" Chem Commun (Camb) 2007, 7, 4726

  63. Carrera C, Digilio G, Baroni S, Burgio D, Consol S, Fedeli F, Longo DL, Mortillaro A, Aime S. "Synthesis and characterization of a Gd(III) based contrast agent responsive to thiol containing compounds" J Dalton Trans 2007, 21, 4980

  64. Gianolio E, Giovenzana GB, Longo DL, Longo I, Menegotto I, Aime S. "Relaxometric and modelling studies of the binding of a lipophilic Gd-AAZTA complex to fatted and defatted human serum albumin" Chem Eur J 2007, 13, 5785
  65. |2005

  66. Aime S, Gianolio E, Longo DL, Pagliarin R, Lovazzano C, Sisti M. "New insights for pursuing high relaxivity MRI agents from modelling the binding interaction of Gd(III) chelates to HSA" Chembiochem. 2005, 6, 818

  67. Geninatti Crich S, Barge A, Battistini E, Cabella C, Coluccia S, Longo DL, Mainero V, Tarone G, Aime S. "Magnetic resonance imaging visualization of targeted cells by the internalization of supramolecular adducts formed between avidin and biotinylated Gd3+ chelates" J Biol Inorg Chem 2005, 10, 78
  68. |2004

  69. Ermondi G, Caron G, Lawrence R, Longo DL. "Docking studies on NSAID/COX-2 isozyme complexes using contact statistics analysis" J Comput Aided Mol Des. 2004, 18, 683

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