Hyperpolarization by means of parahydrogen of biologically relevant substrates is the main focus of the research group. The parahydrogen based hyperpolarization requires the development of tailored precursors of the target agent and the optimization of a suitable hyperpolarization procedure, in order to obtain hyperpolarized molecules that can be used in vivo for diagnostic purposes. In the last years, a procedure named PHIP-SAH (ParaHydrogen Induced Polarization -Side Arm Hydrogenation) has been invented by our group, which allows to generate hyperpolarized metabolites through a steps sequence (i.e. parahydrogenation reaction, polarization transfer, hydrolysis) each of which is investigated in order to optimize the procedure. The research focuses also on the development of new derivatives of biologically relevant molecules, suitable for parahydrogen hyperpolarization. Finally, the hyperpolarized products are used for in vitro and in vivo studies of different pathologies.

Francesca Reineri

Francesca Reineri, PhD

Assistance Professor
Molecular Imaging Center
Department of Molecular Biotechnologies and Health Science
University of Torino
Via Nizza 52
10126 Torino - Italy
Tel: +39 011 6706473
Fax: +39 011 6706458

Hyperpolarized Probes

Hyperpolarized probes

Imaging Metabolism

Imaging metabolism


  • New journal article published in Chemphyschem
  • The hyperpolarization group is a partner of the MSCA-ITN (Marie Slodowska Curie Action, Innovative Training Network) ZULF (Zero and Ultra Low Field). The project involves 9 european partners, renowned groups in the field of NMR and magnetometry. The project aims to the formation of 11 Early Stage Researchers in the innovative fields of Ultra Low Field NMR and Hyperpolarization. For more info visit https://zulf.eu