Our lab aims to develop novel magnetic resonance
imaging (MRI)-based methods for characterizing tumor
microenvironment properties (acidosis, vascularization, hypoxia) in
murine tumor models. We are interested in developing
and validating non-invasive MRI procedures and probes for
improving diagnosis and assessment of treatment effects with
a special focus on tumor metabolism and on antiangiogenic
drugs. Our studies also focus on assessing pH imaging
as a novel biomarker in cancer and in renal diseases.
In addition, we are interested in developing tools for improving the FAIRification
(findable, accessible, interoperable, reusable) of medical image datasets within the Open Science concept.
Our lab bridges theoretical and experimental aspects of
biological research, combining chemistry, biology and
medicine with in vitro and in vivo preclinical studies.
Dario Longo, PhD
Head, Research Unit of Torino
Institute of Biostructures
and Bioimaging (IBB)
Italian National Research Council
(CNR)
Via Nizza, 52
10126 Torino - Italy
Tel: +39 011 6706473
Fax: +39 011 6706458
dariolivio.longo@cnr.it
dario.longo@unito.it
Developing MRI-based probes
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Imaging Tumor Acidosis
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MRI-CEST RENAL pH IMAGING
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Imaging Tumor Angiogenesis
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Upcoming Events
NEWS
- New research article on tumor pH imaging for assessing breast metastatic potential published in
Brisith Journal of Cancer 2021; 124, 207.
Video courtesy of British Journal of Cancer.
- New research article on a novel multislice sequence for 3D MRI-CEST pH imaging published in
Magnetic Resonance in Medicine 2021; 85:1335-1349.
The multislice MRI-CEST sequence is freely available here
- New research article on novel blood-pool CEST agents published in Magnetic Resonance in Medicine 2021; 86:995.
- New research article on a combined approach for evaluating renal perfusion and pH published in NRM in Biomedicine, 2020, 33, e4287.
- New review focussing on imaging tumor metabolism published in Frontiers in Oncology, 2020, 10, 161
- New review focussing on imaging tumor acidosis published in Cancer Metastasis Review 2019; 38:25-49
New book chapters describing basic concepts, acquisition and analysis protocols in preclinical DCE-MRI and CEST pH imaging in kidneys.
Preclinical MRI of the kidney: Methods and Protocols.