Our lab aims to develop novel magnetic resonance imaging
(MRI)-based methods for characterizing tumor
microenvironment properties (acidosis, vascularization,
hypoxia) in murine tumor models. We are interested in
developing and validating non-invasive MRI procedures and
probes for improving diagnosis and assessment of treatment
effects with a special focus on tumor metabolism and on
antiangiogenic drugs. Our studies also focus on assessing pH
imaging as a novel biomarker in cancer and in renal
diseases. In addition, we are interested in developing tools
for improving the FAIRification (findable, accessible,
interoperable, reusable) of medical image datasets within
the Open Science concept.
Our lab bridges theoretical
and experimental aspects of biological research, combining
chemistry, biology and medicine with in vitro and in vivo
preclinical studies.
Dario Longo, PhD
Head, Research Unit of Torino
Institute of Biostructures and Bioimaging (IBB)
Italian National Research Council (CNR)
Via Nizza,
52
10126 Torino - Italy
Tel: +39 011 6706458
email: dario.longo@unito.it dariolivio.longo@cnr.it
Developing MRI-based probes
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Imaging Tumor Acidosis
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MRI-CEST RENAL pH IMAGING
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Imaging Tumor Angiogenesis
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Upcoming Events
- ISMRM 2022 Annual Meeting, London, England
- 17th European Molecular Imaging Meeting 2022 - Thessaloniki, Greece
- CEST workshop 2022
- World Molecular Imaging Congress WMIC 2021
NEWS
- New research article on tumor pH imaging for assessing
breast metastatic potential published in Brisith Journal of
Cancer 2021; 124, 207.
Video courtesy of British Journal of Cancer.
- New research article on a novel multislice sequence for
3D MRI-CEST pH imaging published in Magnetic Resonance in
Medicine 2021; 85:1335-1349.
The multislice MRI-CEST sequence is freely available here
- New research article on novel blood-pool CEST agents published in Magnetic Resonance in Medicine 2021; 86:995.
- New research article on a combined approach for evaluating renal perfusion and pH published in NRM in Biomedicine, 2020, 33, e4287.
- New review focussing on imaging tumor metabolism published in Frontiers in Oncology, 2020, 10, 161
- New review focussing on imaging tumor acidosis published in Cancer Metastasis Review 2019; 38:25-49
New book
chapters describing basic concepts, acquisition and analysis
protocols in preclinical DCE-MRI and CEST pH imaging in
kidneys.
Preclinical MRI of the kidney: Methods and Protocols.