MRI Sequence Development
The MRI sequence development team focuses on the development and optimization of new magnetic resonance imaging (MRI) sequences and protocols tailored to several preclinical applications for Bruker and Aspect Imaging MRI scanners. Led by Dr. Walter Dastr ú and Dr. Dario Longo, the team specializes in MRI data acquisition, image reconstruction and data analysis, covering gadolinium-based, 19F and CEST-MRI applications for improving acquisition time, volume coverage and contrast. Developed sequences are free for downloading by all interested research parties. If the sequences are used for publication purposes, acknowledgments in the manuscript about the sequence are appreciated.
• A single-shot single-slice sequence for CW-CEST imaging
A
single-shot centric encoding RARE-based sequence with an
implemented frequency offsets loop that allows to store all the
images sampled with different frequencies (with CW saturation)
in a single MR scan. This package contains the files and the
instructions for a multislice CEST sequence installation and
first use. The sequence is based on a RARE method developed for
Bruker MRI scanners running with ParaVision 5.1 and with a
modified Magnetization Transfer module.
More information
about the sequence is available in:
"Iopamidol as a
responsive MRI-chemical exchange saturation transfer contrast
agent for pH mapping of kidneys: In vivo studies in mice at 7
T", Longo DL et al;
Magn Reson Med, 2011,
65:202-11, doi: 10.1002/mrm.22608
Download
link for ParaVision 6.0.1
Contacts: dario.longo@unito.it, daisy.villano@unito.it
• A RARE-based sequence for fast multislice CEST imaging
A
fast multislice CEST acquisition scheme has been implemented by
splitting the saturation module into two parts: a first long
saturation pulse that generates the steady-state and a second
short saturation pulse, repeated before each slice, to restore
saturation losses. Each slice is acquired with a
centric-encoding single-shot fast spin echo (RARE) readout. This
package contains the files and the instructions for a multislice
CEST sequence installation and first use. The sequence is based
on a RARE method developed for Bruker MRI scanners running with
ParaVision 6.0.1/360.1.1.
More information about the
sequence is available in:
"A fast multislice sequence for
3DMRI-CEST pH imaging", Villano D et al;
Magn Reson Med, 2021, 85, 1335-1349.
doi:10.1002/mrm.28516
Download
link for ParaVision 6.0.1
Download
link for ParaVision 360.1.1
Contacts: daisy.villano@unito.it
dario.longo@unito.it,
Research groups using our sequences:
- Prof. Robert Gillies - Moffitt Cancer Center - USA
- Prof. Hana Lahrech - Université Grenoble Alpes -
France
- Dr. Afroditi Eleftheriou - Universität Zürich
- Switzerland
- Prof. Simon Walker-Samuel - University College London,
United Kingdom
- Gianluigi Forloni - Istituto di Ricerche
Farmacologiche Mario Negri - IRCCS, Italy
- Stikov - Montreal Heart Institute - Canada
- Joanna Collingwood - Warwick University - United Kingdom
- M.T. McMahon - Kennedy Krieger Institute / The Johns Hopkins University School of Medicine - USA
- Lixin Ma - University of Missouri, Columbia - USA
- Władysław Węglarz - Institute of Nuclear Physics PAN - Poland
- Prof. Aoki Ichio - National Institutes for Quantum and Radiological Science and Technology - Japan
- Thomas Helbich - Medical University of Vienna - Austria
- Olivier Rhéaume Roberge - University of Sherbrooke - Canada
- Wendy Oakden - University of Sherbrooke - Canada
- Brian Roman - University of Chicago - USA
- Salman Shaid - Indiana University Purdue University at Indianapolis - USA
- Esaú Poblador Rodriguez - University of Applied Sciences Wiener Neustadt - USA
- Elad Goren - Weizmann Institute of Science - Israel
- Pedro Enriquez Navas - Bristol Myers Squibb - USA
- Shaowei Bo - Jinan University - China
The sequences are provided for free but to download them please
fill out the form. Of course, their use is under the operator's
responsibility.
All information collected will be stored
securely and will never be used for commercial purposes.
Group Leaders:

