Boron and Gadolinium containing agents for Neutron Capture Therapy
Boron neutron capture therapy (BNCT) is an unconventional radiotherapy that combines low-energy neutron irradiation in the presence of boron-containing compounds at targeted cells.
The low range of the charged particles permits selective destruction of tumor cells without affecting adjacent healthy cells. The delivery of boron should be as selective as possible
to tumor cells in order to increase the amount of internalized B in neoplastic cells, while minimizing uptake in surrounding healthy tissues and permanence in blood, which could
damage normal organs and vessels.
In collaboration with prof. A Deagostino of the Chemistry Department, University of Torino, we synthesized and tested for tumours treatment, different targeted both small- and
nanosized boron carriers:
- AT101/lDL
Alberti D, Geninatti Crich S, Aime S et al. Nanomedicine. 2015 Apr;11(3):741-50
- Rubrocurcumin
Alberti D, Geninatti Crich S, et al. ChemMedChem. 2017 Apr 6;12(7):502-509
- Cholesterol
Alberti D, Toppino A, Geninatti Crich S, Meraldi C, Prandi C, Protti N, Bortolussi S, Altieri S, Aime S, Deagostino A. Org Biomol Chem. 2014 Mar 18;12(15):2457-67
- MEA01
Toppino A, Bova ME, Geninatti Crich S, Alberti D, Diana E, Barge A, Aime S, Venturello P, Deagostino A. t. Chemistry. 2013 Jan 7;19(2):721-8
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