Boron neutron capture therapy (BNCT) is an unconventional
radiotherapy that combines low-energy neutron irradiation in
the presence of boron-containing compounds at targeted cells.
The low range of the charged particles permits selective
destruction of tumor cells without affecting adjacent healthy
cells. The delivery of boron should be as selective as possible
to tumor cells in order to increase the amount of internalized
B in neoplastic cells, while minimizing uptake in surrounding
healthy tissues and permanence in blood, which could damage
normal organs and vessels.
In collaboration with prof. A Deagostino of the Chemistry Department, University of Torino, we synthesized and tested for tumours treatment, different targeted both small- and nanosized boron carriers.